![]() ![]() ![]() Cocaine can also cause seizures by lowering the threshold for seizure initiation. In patients with even mild coronary disease, these hemodynamic changes, plus its vasoconstriction ability, can trigger an acute coronary syndrome.Īsides from the myocardium, cocaine can also increase the risk of ischemic stroke. Cocaine significantly increases myocardial oxygen requirements, heart rate, and cardiac output. Long-term use of cocaine can also alter cardiac histology leading to fibrosis, myocarditis, and contraction band necrosis. The increased catecholamine levels can induce life-threatening arrhythmias, and at the same time, the local anesthetic properties of cocaine further impair impulse conduction, leading to re-entry ventricular arrhythmias. The adverse effects on the heart are due to the direct actions of cocaine by inhibiting the reuptake of catecholamines into the nerve endings. pesticides.Patients who abuse cocaine risk life-threatening consequences, including tachydysrhythmia, severe hypertension, acute coronary syndrome, stroke, acute myocardial and renal failure, seizure, hyperthermia, cocaine-induced rhabdomyolysis, and fetal/maternal morbidity and mortality. In popular usage toxicant more commonly (though inaccurately) refers to man-made (synthetic) toxic substances e.g. All toxins are toxicants, but not all toxicants are toxins. A toxin is a toxicant produced by a living organism (generally metabolic products that have evolved as defense mechanisms). Note: A toxicant is the umbrella term for any toxic substance. Toxicology Resources: Toxicology and toxinology resources on the web.Toxicological Conundrums: Toxicology emergency management in clinical context.Antivenoms: Chemical management of toxins and envenoming.Toxins: Assessment and management of envenoming (Toxinology).Antidotes – Chemical management for ingested drugs, toxicants and toxins.Drugs and Synthetic Toxicants: Assessment and management of poisoning.Toxicology Basics: Principles of RRSIDEAD in toxicology and toxinology.The Toxicology Library contains toxicology tutorials clinical conundrums analysis of drugs, antidotes, envenomings applied clinical context of basic pharmacology and physiology. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |